Joachim Seipelt

Nuvonis Vero Cell Banks (R&D and GMP) Vero cells are widely used for manufacturing a variety of viruses and vectors. Nuvonis provides “ready to use” GMP Master and GMP Working Cell Banks. Vero cell banks are produced under serum and animal-free media conditions. Vero cell banks are immediately available for GMP manufacturing and are fully characterized including tumorigenicity testing at the end of production level (EPCB). Nuvonis Avian Cell Banks CCX.2C4 and CCX.E10 (R&D and GMP) Avian cells are suitable for the production of a variety of viruses, such as Vaccinia, Orthomyxoviridae, HSV Type I, Pseudorabies, Reovirus, Parainfluenza, Newcastle Disease Virus, MVA etc. Importantly, avian cell lines can replace Chicken Embryo Fibroblasts (CEF) or cultivation of viruses in embryonated hen’s eggs. Nuvonis has developed a novel continuous avian cell line (CCX) from primary quail (Coturnix japonica). Nuvonis avian cell banks are available both for adherent growth and growth in suspension. **Process Development Services **The Nuvonis team is highly experienced in developing and optimizing up- and downstream vaccine production processes and all aspects of vaccine development. Amongst other optimization techniques, we are offering a proprietary and efficient virus purification process for the generation of high-purity vaccine bulk drug substance, meeting regulatory requirements in terms of host cell DNA and host cell protein impurities.